Human IL-6 R alpha/CD126 Protein, His Tag

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Interleukin 6 receptor (IL-6R), also known as CD126 (cluster of differentiation 126), is a type I cytokine receptor. IL6Ra is part of the IL-6R. Low concentrations of the soluble f orm of the IL-6 receptor (SIL-6R) act as agonists for IL-6 activity. Dysregulation of IL6 and this receptor has been implicated in the pathogenesis of many diseases such as multiple myeloma, autoimmune diseases and prostate cancer. Furthermore, high levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases, as well as in cancer. Specifications Synonyms IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80 Uniprot No. P08887 Source Recombinant Human IL-6RA Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu 20 - Pro 365. Molecular Weight The protein has a predicted MW of 39.4 kDa. And it migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Purity > 95% as determined by SDS-PAGE. Endotoxin Show more