Recombinant Cynomolgus CTLA-4/CD152 Protein, hFc Tag _ 96592ES

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CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. Humanor mouse CTLA-4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence. It is found as a covalent homodimer of 41-43 kDa. Product Information Product Information. Catalog Number Size Recombinant Cynomolgus CTLA-4/CD152 Protein,hFc Tag 96592ES25 25 μg 96592ES60 100 μg 96592ES76 500 μg Product Properties Synonyms CTLA-4,CD152 Species Cynomolgus Expression Sequence Ala37-Asp161,with C-terminal hIgG Fc Accession XP_005574071.1 Tag C-hFc Tag Expression System HEK293 Molecular Weight 43-50 kDa (Reducing) Purity > 95% as determined by SDS-PAGE. Endotoxin < 0.1 EU/μg Formulation PBS, pH7.4. Appearance Lyophilized Powder Reconstitution Method Reconstitute at 0.1-1 mg/mL according to the size in ultrapure water after rapid centrifugation. Product Features High activity, high purity, low endotoxin, high lot-to-lot consistency Application Example ELISA Data: Immobilized B7-1/CD80 His Tag,Human at 5.0 μg/mL (100 μL/well) can bind CTLA-4/CD152 Fc Chimera,Cynomolgus with EC50 of 11.18-18.05 ng/mL. Storage Store at -25 ~ -15°C, valid for 1 year after receipt. After reconstitution, store at 2~8°C under sterile conditions, valid for 7 days. After reconstitution, store at -85 ~ -65°C under sterile conditions, valid for 3 months. Documents: Manuals 96592_Manual_HB20260421 Show more