MCAS and Histamine Report
For you if you live with flushing, hives, food reactions, or a growing list of sensitivities, and suspect your mast cells are involved. You get a PDF report built around one short, ranked list of what to eat, add, and avoid. You need the raw DNA file you already have from 23andMe, Ancestry, MyHeritage, or another DNA service. No new test. Private by design. The report runs in your browser. Your DNA is never uploaded or stored. Ready in 3 to 10 minutes, with a 14-day refund if you have not started generating it. Get a free example report before you buy If you react to more and more things and your allergy tests keep coming back clear, part of the answer may be in the genes that switch your mast cells on and clear the histamine they release. For some people, mast cell activation syndrome (MCAS) feels like being allergic to almost everything. Flushing, hives, stomach pain, brain fog, a racing heart, and reactions to foods or medicines can come in episodes, across the skin, gut, nervous system, and heart. Mast cells are immune cells that store histamine and other chemical messengers, and in MCAS they release them too easily and too often. MCAS is hard to manage partly because the problem can sit at several points along one chain: the signals that switch mast cells on, the background inflammation that keeps them primed, and how quickly your body clears the histamine they release. Genes influence each of those steps, and a protocol aimed at the wrong step can leave you doing everything right with little to show for it. This report reads the genes across the mast cell and histamine pathways and turns them into a ranked, food-first protocol matched to your variants. Why the same MCAS protocol helps one person and not another Three examples from this report: IL-33 and reactions without an allergy. IL-33 is an alarm signal released when the gut or airway lining is inflamed. In a study of lab-grown human mast cells, it prompted them to release inflammatory messengers without IgE. IgE is the antibody most allergy tests measure, so this may help explain reactions when those tests come back clear. Variants near IL-33 were linked to asthma in a genetic study of more than 26,000 people. For carriers, the report suggests vitamin C, quercetin, and vitamin D, and flags green tea extract (EGCG) to avoid. ALDH2 and the alcohol flush. ALDH2 clears aldehydes, the by-products of breaking down alcohol and, further along, histamine. Slow variants cause the facial flush some people get from one drink, seen in about a third of people of East Asian ancestry. In a small study of Japanese adults with asthma, alcohol narrowed airways in 3 of 16 with the usual gene and 10 of 14 with one slow copy, and the reaction tracked rises in blood acetaldehyde and histamine. The report points carriers away from alcohol and toward a low-histamine diet, with vitamin C and magnesium. IL-6 and a primed mast cell. In laboratory work at the US National Institutes of Health, long exposure to IL-6, an inflammatory messenger, made human mast cells grown in the lab multiply and react more strongly when triggered. The report links some IL-6 variants to higher background inflammation and, for carriers, suggests fruits, vegetables, herbs, and spices over processed foods, processed omega-6 oils, and smoking. Those are three of the mechanisms. The report covers 67 genes across eight areas. What the report analyzes Mast cell growth and activation. What switches your mast cells on, through IgE or around it, and the allergy-leaning Th2 messengers that keep reactions going (KIT, FCER1A, IL-33, IL-4, IL-4R, IL-5, IL-13). Inflammatory signaling. How strongly your body makes the inflammatory messengers that prime mast cells (IL-6, TNF-alpha, TGFB1). Histamine production and clearance. How much histamine you make, and how quickly your gut and cells break it down and clear what is left (HDC, AOC1/DAO, HNMT, MAOA, MAOB, ALDH2). Methylation and B vitamins. The methylation cycle that HNMT relies on to break down histamine inside your cells, and the forms of folate and B vitamins the report suggests for your variants (MTHFR, MTHFS, MTHFD1, DHFR, SLC19A1, MTR, MTRR, PEMT, BHMT, CBS, COMT, NBPF3). Detoxification. How you process compounds such as tyramine, glutamate, caffeine, and some medicines (FMO3, NAT1, NAT2, CYP1A2, CPS1). Vitamins D and A, and iron. How you activate vitamins D and A, and how you transport and store iron (VDR, GC, CYP2R1, BCO1, HFE, TF, TMPRSS6). Gut, oxalate, and uric acid. Lactose tolerance and B12 absorption in the gut, and how your body handles oxalate and uric acid (FUT2, LCT, AGXT, GRHPR, HOGA1, SPP1, SLC2A9, ABCG2). Dietary and metabolic genetics. How your body processes fat, cholesterol, and carbohydrate, and the eating pattern the report suggests for your variants (APOE4, FADS1, FADS2, PPARG, PPARA, ADIPOQ, CETP, LIPC, FTO, LEPR, ACE, and more). What you get Every Noorns report follows the same structure, built to cut through overwhelm and point you to action: A Recommendations Summary. A ranked, prioritized list of nutrients, foods, and lifestyle factors scored by the combined strength of your genetic signal. The practical starting point. A Conflicts section. Where genes pull in different directions on the same intervention, both scores are shown instead of hiding the tension. Gene-by-gene pages. Plain-English explanations of every gene, your specific variants, and the targeted changes tied to each one. A Science Deep Dive. The biology of mast cell activation, how MCAS differs from mastocytosis, histamine metabolism, and why histamine symptoms can shift across the menstrual cycle, for when you or your practitioner want to understand the mechanisms. Who it is for This report is for anyone living with flushing, hives, itching, stomach reactions, or a growing list of food and medicine sensitivities who suspects their mast cells or histamine intolerance are involved, with or without a diagnosis. Practitioners can use it before designing a protocol. This report and the Eczema and Skin Report share the same mast cell and histamine core. If eczema or reactive skin is part of your picture, choose the Eczema and Skin Report, which adds the skin barrier gene FLG and two more immune genes. If your reactions are mainly in your gut, head, or heart, choose this report. It is built around whole-body mast cell reactions, and it adds TNF-alpha, an inflammatory messenger gene the skin report does not read. For autoimmune-like patterns or chronic inflammation, see the Immune Balance Report, which adds 14 more immune genes. Your DNA file never leaves your computer When you generate this report, the analysis runs entirely inside your own web browser, on your own device. We do not upload your DNA. We do not store it. We cannot read it. Privacy is enforced by architecture, not by a policy you have to trust. How it works Buy the report. You get a sign-in link by email. There is no password to remember. Add your DNA file. Select the raw data file you already have from 23andMe, Ancestry, MyHeritage, or another DNA service. It is read on your computer and never sent to us. Generate and save. The analysis takes three to ten minutes in your browser, then hands you a PDF to keep. Keep the tab open while it runs. A note on medical care This report is education about your genes and your nutrition. It does not diagnose MCAS or mastocytosis, or replace tryptase and other lab tests. Talk to your doctor before you start a supplement or change a medication.
